compete
 

Designação do projeto | PhageSTEC – Encapsulated bacteriophages for pre-slaughter interventions to reduce to Shiga toxin-producing E. coli (STEC) in ruminants

Código do projeto | POCI-01-0145-FEDER-029628 e PTDC/CVT-CVT/29628/2017

Objetivo temático |Reforçar a investigação, o desenvolvimento tecnológico e a inovação

Região de intervenção | Norte

Instituição Proponente | UNIVERSIDADE DO MINHO

Instituição Participante | INSTITUTO NACIONAL DE INVESTIGAÇÃO

AGRÁRIA E VETERINÁRIA, I.P. | LABORATÓRIO IBÉRICO INTERNACIONAL

DE NANOTECNOLOGIA (LIN) | UNIVERSIDADE DE TRÁS-OS-MONTES E ALTO DOURO

Data de início | 26 de Julho de 2018

Data de conclusão | 31 de Dezembro de 2021

Custo total elegível | 233.992,70 €

Custo total elegível UTAD | 18.750,00 €

 

Resumo:

Singa toxin-producing E. coli (STEC) bacteria are emerging foodborne pathogens worldwide. They are natural residents of the cattle gut and are transmitted to humans through contaminated food. Only specific srotypes (e.g. O157, O104) are problematic within a large group of commensal E. coli microbiota. Bacteriophages are viruses that only infect and kill bacterial cells. They recognize the host through bacterial cell receptors, which defines their lytic range. Isolation of bacteriophages able to infect one single E. coli serotype is possible and will be used to recognize bacterial surface O – antigens as receptors. We will use naturally occurring bacteriophages against the most relevant STEC serotypes of Portugal. They will be encapsulated and administered to live ruminat animals, as a way to condition the animal gut microflora gently and favourably, thereby facilitating international food trade and improving animal and public health.