compete
 

Designação do Projeto | GLUTEN2TARGET – Optimizing natural low toxicity of wheat for celiac patients through a nano/microparticles detoxifying approach

Código do projeto | POCI-01-0145-FEDER-029068 e PTDC/BAA-AGR/29068/2017

Objetivo temático | Reforçar a investigação, o desenvolvimento tecnológico e a inovação

Região de intervenção | Norte | Alentejo

Instituição Proponente | UNIVERSIDADE DE TRÁS-OS-MONTES E ALTO DOURO

Instituição Participante | INSTITUTO NACIONAL DE INVESTIGAÇÃO AGRÁRIA E VETERINÁRIA, I.P.

Data de início | 01 de Junho de 2018

Data de conclusão | 30 de Novembro de 2021

Custo total elegível | 239.923,90 €

Custo total elegível UTAD | 233.673,90 €

 

Resumo:

Wheat is one of the major sources of protein and energy in the human diet. It contains a protein complex, the gluten, which triggers and maintains the enteropathy in celiac disease, a common immune based disorder of the small intestine. At present, the only effective treatment is a gluten-free diet. Nevertheless, compliance is demanding and new treatment strategies for celiac disease are desired by patients and clinicians. The aim of this study is to create a firm basis for the development of a therapy that allows celiac patients to eat wheat-based food products. Initially, we will evaluate wheat biodiversity to select potential low-toxicity varieties. Thus, we will develop gluten-specific nano/microparticles, with the function of sequestering the toxic proteins/peptides. Considering the simultaneous application of low-toxicity wheat varieties and a glutentargeted technology to decrease gluten immunogenicity, we expect to influence the next generation of therapies for celiac disease.